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Antihistamine for rash

Dr Karen Martin
Reviewed by Dr Karen MartinReviewed on 10.10.2024 | 3 minutes read
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Antihistamine medication plays a crucial role in preventing the escalation of histamine levels within the body, effectively reducing allergy-related symptoms. However, it is essential to recognize that antihistamines may not provide relief if the rash stems from causes unrelated to allergies. These medications are widely available over-the-counter in the form of tablets, liquids, and creams. Understanding the underlying trigger for the rash is paramount in determining the most suitable treatment approach. Allergies often manifest as pruritic raised rashes resulting from reactions to various triggers such as food, pollen, viral infections, insect bites, or chemicals. This can be tested with a skin prick test, to see whether you have an allergy to certain groups

Doctor’s advice

Which antihistamine should you choose?

Tablets and liquids exert a more systemic effect compared to creams, making them preferable for broader coverage. However, if the affected area is localized and small, creams can offer equally effective relief. There exists a wide range of antihistamine tablets, including once-daily options like loratadine, cetirizine, and fexofenadine. While these medications are considered less sedating than others available over-the-counter, they may not be as potent in managing symptoms. Chlorpheniramine can be taken up to six times daily in adults and often provides greater relief due to its increased frequency of administration. However, it is important to note that chlorpheniramine carries a higher likelihood of inducing drowsiness, necessitating caution when engaging in activities such as driving or tasks demanding alertness.

When should you consider seeking medical attention?

If you have tried over-the-counter antihistamines for your rash but find that the symptoms persist without improvement, consulting your doctor is advisable. This becomes particularly important if the affected area exhibits signs of infection, such as warmth, increased size, inflammation, or the presence of pus. Depending on your doctor's diagnosis, they may consider prescribing a different class of antihistamines, antibiotics, or antifungals. In cases where these interventions prove insufficient, oral steroids might be introduced. Steroids are notably more potent but can also entail significant side effects that require careful consideration.

Should anyone avoid antihistamines?

Certain individuals should exercise caution when taking antihistamines. If you have severe kidney or liver problems, it is advisable to avoid these medications unless under the guidance of a healthcare professional. Similarly, if you are pregnant or breastfeeding, consulting your doctor before initiating antihistamine treatment is essential. If you are uncertain about potential interactions with other medications, speaking with your pharmacist or doctor is recommended.

Drowsiness represents the most common side effect associated with antihistamine use. Although some formulations are less sedating, it is important to acknowledge that all medications in this class can induce drowsiness to some extent. Additional side effects may include dizziness and headaches. While allergic reactions to antihistamines are uncommon, they are possible. If you experience an allergic reaction, seeking urgent medical attention is imperative.

How to prevent hives

Preventing the recurrence of hives is best achieved by identifying and avoiding triggers responsible for the rash. In situations where triggers such as dust or pollen are challenging to avoid completely, regular antihistamine usage may be beneficial, particularly since triggers can unknowingly reoccur.

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This article has been written by UK-based doctors and pharmacists, so some advice may not apply to US users and some suggested treatments may not be available. For more information, please see our T&Cs.
Dr Karen Martin
Reviewed by Dr Karen Martin
Reviewed on 10.10.2024
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