treatment icon


Dr Karen Martin
Reviewed by Dr Karen MartinReviewed on 19.10.2023 | 2 minutes read

Difflam is a branded version of the anti-inflammatory and pain relief medication benzydamine. It primarily comes in three formulations: mouth spray, mouth rinse and lozenges. It is important that it is taken with food as it can cause stomach irritation. This medication is not available in the US.

Doctor’s advice

Who is it for?

Difflam is specifically formulated to help with inflammation in the mouth and throat. For throat conditions, it is useful for people suffering from tonsillitis or a sore throat. It can also help with mouth ulcers, pain after dental surgery and inflammation of the mouth that can happen if you have had radiotherapy or chemotherapy to the mouth or jaw area (known as radiation mucositis).

How does it work?

Difflam is a nonsteroidal anti-inflammatory drug (NSAID) from the same family as aspirin and ibuprofen. Because of this, make sure you aren't taking Difflam alongside other anti-inflammatories, as this can upset your stomach.

Difflam's anti-inflammatory effect works by blocking the body's production of a substance called prostaglandins, which are released in response to illness or injury. Prostaglandins can cause pain and inflammation to notify the person they are unwell. They can stop the pain, inflammation, and even fever by stopping prostaglandin production.

Difflam also has biocidal properties, which means that it can kill microorganisms, such as bacteria and fungi. This means that it can also help fight against infection in the throat or mouth.

Should anyone avoid taking it?

  • Like all medications, don’t take them if you have previously had an allergic reaction to the medication, if you have severe kidney or liver problems, or if you have other medications or medical conditions where you would normally discuss it with your doctor or pharmacist before starting something new.
  • Do not take Difflam if you are trying to get pregnant or are pregnant already.
  • If you are asthmatic and haven’t had anti-inflammatories before, they can sometimes cause an acute asthma attack.
  • The mouth rinse is not suitable for ages under 13 years. As for the lozenge, due to its nature, it isn’t suitable for any child under the age of 6 years.
  • If you have a known stomach ulcer or inflammatory bowel disease, you should avoid taking Difflam unless recommended by your doctor.

Are there any side effects?

As with any medications, some people are bound to get some unwanted side effects. An uncommon (1 in 1000 people) side effect includes numbness and/or stinging in the mouth and/or throat. Very rare side effects (1 in 10,000 people) include difficulty breathing, swelling, and itchy skin.

Was this helpful?

Was this helpful?

Dr Karen Martin
Reviewed by Dr Karen Martin
Reviewed on 19.10.2023
App Store
Google Play
Piff tick
Version 2.28.0
© 2024 Healthwords Ltd. All Rights Reserved