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Hormone Replacement Therapy and Breast Cancer Risk: What Women Need to Know

Written by healthwords.ai's team of doctors and pharmacists based in UK | Updated: 30 Sep 2025 | 3 min read

Hormone Replacement Therapy (HRT) is a treatment that helps women manage menopause symptoms, like hot flashes, mood swings, and bone health issues. HRT can improve life during menopause, but it may slightly raise the risk of breast cancer. Knowing how HRT affects breast cancer risk helps women make smart choices for their health.

What is HRT?

HRT replaces oestrogen, a hormone that drops during menopause. This drop can cause symptoms like night sweats and mood changes. HRT helps balance hormones and relieves these symptoms.

Types of HRT:

  • Oestrogen-only HRT: Usually for women who have had their womb removed. Using it with an intact womb can raise the risk of womb cancer.
  • Combined HRT: Has both oestrogen and progestogen. For women with a womb, it lowers womb cancer risk but may slightly raise breast cancer risk more than oestrogen-only HRT.
  • Localised HRT: Creams, rings, or pessaries used in the vagina for dryness. It does not affect the whole body.

HRT and Breast Cancer Risk

Some studies show that combined HRT can slightly increase breast cancer risk, especially if used for a long time.

Risk factors include:

  • Type of HRT: Combined HRT has a higher risk; localised HRT does not.
  • Duration: Using HRT for longer periods, especially combined HRT, can increase the risk. Regular check-ins with your doctor are recommended.
  • Personal/family history: If you or your family have had breast cancer, the risk may be higher.

Most research indicates that the risk returns to normal within five years of stopping HRT. Many women still find that HRT improves their quality of life.

Factors That Affect Breast Cancer Risk

  • Age: Starting HRT closer to menopause is associated with lower risks. Starting later can increase risk.
  • Family history: Women with a family history of breast cancer should talk to their doctor.
  • Lifestyle: Smoking, alcohol, and being overweight raise breast cancer risk. Healthy habits help lower risk.
  • Duration of use: Short-term use (under five years) has less impact; more prolonged use may increase risk.

Alternatives to HRT

HRT isn’t suitable for everyone, so there are other ways to manage menopause symptoms.

  • Lifestyle changes can be very effective, including regular exercise, a balanced diet, reducing alcohol, and practising stress-reduction techniques such as yoga or mindfulness.
  • Non-hormonal medicines: some antidepressants e.g., SSRIs or SNRIs) can help reduce hot flushes and improve mood.
  • Herbal supplements such as black cohosh, red clover, or evening primrose oil may help alleviate some symptoms. While a few studies suggest mild symptom relief, evidence is limited and mixed, so it’s important to consult a doctor before using any herbal remedy, especially if you are taking other medications or have underlying health conditions. Always check with a doctor first.
  • Cognitive Behavioural Therapy (CBT): Can help women cope with the emotional impact of hot flushes, night sweats, and mood swings, improving sleep and overall well-being.”

By combining these approaches, many women find they can manage menopausal symptoms safely and effectively without HRT.

Staying Healthy While on HRT

  • Yearly check-ups: Review symptoms and adjust HRT as needed.
  • Breast checks: Self-checks and regular mammograms for women over 50 or at higher risk.
  • Healthy habits: Eat well, exercise regularly, and limit alcohol consumption.
  • Mental health: Talk to your doctor if you notice mood changes or anxiety.

Weighing the Benefits and Risks

  • Better quality of life: HRT alleviates menopause symptoms and helps women maintain their activity levels.
  • Stronger bones: Oestrogen in HRT helps prevent osteoporosis.
  • Cancer risk: HRT slightly increases some cancer risks, but many women find that the relief outweighs the risk.
  • Duration: Short-term use (<5 years) is generally safe; prolonged use requires careful monitoring.

Making the Right Choice

  • Discuss your symptoms and health goals with your doctor.
  • Consider your family history and lifestyle: These factors can influence your HRT choices.
  • Consider other health risks: Some women may require alternative options.
  • Stay informed: Research on HRT is ongoing; reliable updates help guide decisions.

When to See a Doctor

See your doctor if:

  • Symptoms are severe or affect daily life.
  • You have a family history of breast cancer or hormone-related cancers.
  • You have been on HRT for a long time.
  • You notice any changes in your breasts, such as lumps or pain.

Regular check-ups ensure HRT is safe and effective.

Conclusion

HRT can help many women manage menopause symptoms, but it's essential to know both the benefits and possible risks. Regular doctor visits, healthy habits, and staying informed help women make safe, effective choices and maintain comfort and health during menopause.